Direct Catalytic H/T ExchangeTritium-Labeling Without Precursor Synthesis

Direct catalytic H/T exchange can be achieved by application of homogeneous or heterogeneous catalysts in presence of tritium gas. The most popular homogenous catalyst is [Ir(cod)(PCy₃)(py)]PF₆, a commercially available compound also known as Crabtree’s catalyst. It mainly promotes H/T exchange in aromatic ortho-positions of directing functional groups. 

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